I've had my LR4 a little over a month. Tires were upgraded, no balance issues. No complaints, but I've noticed a slight wind noise from around the 2nd moon roof when driving on the highway. Been through the car wash a couple of times and it doesn't leak, so not sure what causes the noise. Turn the radio up to 8 and you don't hear it.
I've followed the manual's instruction of keeping the speed at 68 MPH for the first 1K miles and avoid aggressive acceleration during the initial break in period.
Fantastic vehicle to drive on road and off road. I plan on adding a grill, winch, roof rack, sliders and under carriage protection. This will take a while, but I've wondered how it will effect the handling, noise and smooth ride.
I find the seats comfortable. A guy who owns an Infiniti SUV and an Audi was impressed with the seats and commented that he liked them better than his vehicles.
Mix of city/hwy - 15 MPG average